Phage-ligand Technology
Get Phage-ligand Technology essential facts below. View Videos or join the Phage-ligand Technology discussion. Add Phage-ligand Technology to your topic list for future reference or share this resource on social media.
Phage-ligand Technology

The Phage-ligand technology is a technology to detect, bind and remove bacteria and bacterial toxins by using highly specific bacteriophage derived proteins.[1]


The host recognition of bacteriophages occur via bacteria-binding proteins that have strong binding affinities to specific protein or carbohydrate structures on the surface of the bacterial host. At the end of the infection life cycle the bacteria-lysing Endolysin is synthesized and degrades the bacterial peptidoglycan cell wall, resulting in lysis (and therefore killing) of the bacterial cell.


Bacteriophage derived proteins are used for detection and removal of bacteria[2][3] and bacterial components (especially endotoxin contaminations) in pharmaceutical and biological products, human diagnostics, food,[4][5] and decolonization of bacteria causing nosocomial infections (e.g. MRSA). Protein modifications allow the biotechnological adaption to specific requirements.

See also

Affinity magnetic separation


  1. ^ Technological background
  2. ^ Kretzer JW, Lehmann R, Banz M, Kim KP, Korn C. Loessner MJ (2007) Use of high affinity cell wall-binding domains of bacteriophage endolysins for immobilization and separation of bacterial cells. Appl Environ Microbiol 73:1992-2000
  3. ^ Rozand, C., Feng, P. C. H. (2009). Specificity analysis of a novel phage-derived ligand in an Enzyme-linked fluorescent assay for detection of Escherichia coli O157:H7. J. food protection 72, 1078-1081.
  4. ^ "Bacteriophages - New Applications in Food Microbiology" (PDF), bioFood n°3 December 2006, page 2, archived from the original (PDF) on 1 October 2011
  5. ^ Applications of the phage-ligand technology (endotoxin detection, endotoxin removal, food safety testing)

  This article uses material from the Wikipedia page available here. It is released under the Creative Commons Attribution-Share-Alike License 3.0.



Top US Cities was developed using's knowledge management platform. It allows users to manage learning and research. Visit defaultLogic's other partner sites below: : Music Genres | Musicians | Musical Instruments | Music Industry